R. J. Woods

Ion exchange biomaterials to capture daptomycin and prevent resistance evolution in off-target bacterial populations

This study shows ion exchange biomaterials can capture daptomycin in the gut, preventing resistance evolution in off-target bacteria.

Genetic determinants of antibiotic resistance and the evolution of trade-offs during adaptation in a single patient

This study tracks genetic and phenotypic changes in antibiotic resistance in a single patient's infection over time, revealing no pan-resistant isolate and complex patterns of collateral sensitivity and combination therapy responses.

The effective population size and mutation rate of influenza A virus in acutely infected individuals

The paper estimates the within-host effective population size and mutation rate of influenza A virus in acute infections using sequence data from 200 patients.

Hyper-Truncated Glycans Augment the Activity of Neutrophil Granule Myeloperoxidase

This study identifies hyper-truncated glycans on neutrophil myeloperoxidase (MPO) that enhance enzyme activity and inhibition potential, revealing their functional role in immune responses.

PD-L1 glycosylation and its impact on binding to clinical antibodies

This study investigates PD-L1 glycosylation patterns and their impact on interactions with PD-1 and clinical antibodies, revealing site-specific glycan structures and potential functional implications.

Virus-Receptor Interactions of Glycosylated SARS-CoV-2 Spike and Human ACE2 Receptor

The paper characterizes glycosylation of SARS-CoV-2 Spike and ACE2 using glycomics and simulations to understand their interactions and guide immunogen design.

An adjunctive therapy administered with an antibiotic prevents enrichment of antibiotic-resistant clones of a colonizing opportunistic pathogen

This study shows that cholestyramine, when used with daptomycin, reduces the spread of antibiotic-resistant Enterococcus faecium in mice.

Glycosaminoglycan binding motif at S1/S2 proteolytic cleavage site on spike glycoprotein may facilitate novel coronavirus (SARS-CoV-2) host cell entry

This study identifies a glycosaminoglycan-binding motif in SARS-CoV-2 spike glycoprotein that enhances binding to heparin, suggesting a role in host cell entry and potential for carbohydrate-based therapies.

Analysis of the SARS-CoV-2 spike protein glycan shield: implications for immune recognition

The paper analyzes SARS-CoV-2 spike protein glycan structures and their impact on immune recognition, finding that glycans extensively shield the protein surface from antibodies.

Allosteric regulation of lysosomal enzyme recognition by the cation-independent mannose 6-phosphate receptor

This study investigates how the CI-MPR receptor binds and releases carbohydrates through allosteric domain cooperativity using biophysical methods and crystal structures.

A glycogenin homolog controls Toxoplasma gondii growth via glycosylation of an E3 ubiquitin ligase

This study identifies Gat1, a glycogenin homolog, as essential for adding the terminal sugar to Skp1 in Toxoplasma gondii, which is critical for parasite growth.

Antibiotics can be used to contain drug-resistant bacteria by maintaining sufficiently large sensitive populations

This study shows that maintaining large populations of drug-sensitive bacteria can delay the rise of drug-resistant bacteria using containment strategies.

Enriched pathogen diversity under host-type heterogeneity and immune-mediated competition

The paper examines how host-type heterogeneity and immune-mediated competition affect pathogen diversity using a theoretical model inspired by rotavirus.

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus

This study shows that RNA viruses evolve high mutation rates as a byproduct of selection for faster replication, not because of adaptive advantages.

Stochastic processes dominate the within and between host evolution of influenza virus

This study uses viral sequence data from a community-based cohort to estimate within-host population dynamics and transmission bottlenecks of influenza A virus, finding that stochastic processes dominate its evolution.

Quantitative Protein Topography Measurements By High Resolution Hydroxyl Radical Protein Footprinting Enable Accurate Molecular Model Selection

This paper introduces HR-HRPF to measure solvent accessible surface area and evaluates its ability to distinguish accurate molecular models.