M. M. Lin

Molecular mechanism underlying SNARE-mediated membrane fusion enlightened by all-atom molecular dynamics simulations

This study uses molecular dynamics simulations to propose a mechanism for SNARE-mediated membrane fusion, emphasizing local molecular events over general membrane properties.

Kinetic and thermodynamic allostery in the Ras protein family

This study identifies kinetic and thermodynamic allostery in Ras protein isoforms using molecular simulations, showing how these mechanisms explain differences in catalytic activity and allosteric regulation.

Resonant fluctuations of selection pressure exponentially accelerate fitness valley crossing

The paper derives an equation showing that resonant selection pressure fluctuations exponentially accelerate fitness valley crossing in protein evolution.

All-atom molecular dynamics simulations of synaptic vesicle fusion I: a glimpse at the primed state

The paper uses molecular dynamics simulations to study the primed state of synaptic vesicles, revealing a spring-loaded configuration of trans-SNARE complexes bound to synaptotagmin-1 and complexin-1.

All protein aggregates will thermodynamically order

The paper develops a statistical mechanical theory predicting that all protein aggregates will thermodynamically order, regardless of sequence or environmental conditions.

Genome-wide DNA polymorphisms in four Actinidia arguta genotypes based on whole-genome re-sequencing

The paper identifies genome-wide SNPs and InDels in four Actinidia arguta genotypes using whole-genome re-sequencing and links them to functional genes involved in stress responses and hormone signaling.