Author

K. A. Reynolds

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Organism:E. coli· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:metabolism & bioenergetics· 1 Assay:protein structure· 1

Frequent Co-Authors

S. Thompson· 3 shared C. Ingle· 2 shared A. Blevins· 1 shared J. W. McCormick· 1 shared M. A. X. Russo· 1 shared M. E. Di Salvo· 1 shared M. M. Lin· 1 shared T. Kortemme· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

S. Thompson

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Author profile →

4 papers

Recent·Most cited

The Genetic Landscape of a Metabolic Interaction

T. N. Nguyen, C. Ingle, S. Thompson, K. A. Reynolds

The paper quantifies how DHFR mutations affect TYMS growth rates using deep mutational scanning, revealing metabolic context's role in enzyme mutational tolerance.

bioRxiv · May 28, 2023Biochemistry

Resonant fluctuations of selection pressure exponentially accelerate fitness valley crossing

M. E. Di Salvo, K. A. Reynolds, M. M. Lin

The paper derives an equation showing that resonant selection pressure fluctuations exponentially accelerate fitness valley crossing in protein evolution.

bioRxiv · Jan 3, 2022 · PreprintEvolutionary Biology

Structurally Distributed Surface Sites Tune Allosteric Regulation

J. W. McCormick, M. A. X. Russo, S. Thompson, A. Blevins, K. A. Reynolds

The paper investigates how mutations affect allosteric regulation by analyzing the impact of 1548 DHFR single mutations on allostery using a high-throughput assay.

bioRxiv · Mar 11, 2021Biophysics

Modulating the cellular context broadly reshapes the mutational landscape of a model enzyme

S. Thompson, Y. Zhang, C. Ingle, K. A. Reynolds, T. Kortemme

The paper shows that the absence of the protease Lon in E. coli reshapes the mutational landscape of DHFR, increasing the proportion of advantageous mutations.

bioRxiv · Nov 20, 2019 · PreprintBiophysics