S. J. Tans

Structural basis of membrane targeting and coatomer assembly by human GBP1

This study determines the cryo-EM structure of human GBP1 dimer and coatomer assemblies, revealing how nucleotide binding and hydrolysis drive membrane targeting and coatomer formation.

Mother cells control daughter cell proliferation in intestinal organoids to minimize proliferation fluctuations

The paper tracks cell proliferation in mouse intestinal organoids and shows symmetric proliferative behavior between sister cells minimizes fluctuations.

Minimizing cell number fluctuations in self-renewing tissues with a stem cell niche

The paper models cell proliferation in self-renewing tissues with a stem cell niche and finds that minimizing fluctuations requires maximizing growth rate differences and using symmetric divisions.

Direct observation of Hsp90-induced compaction in a protein chain

This study uses optical tweezers to show Hsp90 induces local contractions in unfolded protein chains, leading to global compaction and suppression of misfolding and aggregation.

Single Cell Variability of CRISPR-Cas Interference and Adaptation

The paper studies CRISPR-Cas interference and adaptation in E. coli, finding cell-to-cell variability in clearance times due to primed adaptation, with Cascade binding as the main source of heterogeneity.

Weak catch bonds make strong networks

This paper shows that weak catch bonds in cytoskeletal networks enhance mechanical strength and deformability by enabling dissociation-on-demand, contrasting with the traditional strength-on-demand model.

The ribosome modulates folding inside the ribosomal exit tunnel

The paper investigates how the ribosomal exit tunnel affects the folding of a small zinc-finger domain, finding that electrostatic interactions, not just confinement, contribute to folding acceleration and stabilization.

Polypeptide collapse modulation and folding stimulation by GroEL-ES

This study shows GroEL-ES enhances polypeptide collapse, directly stimulating folding by pulling chains into its cavity and promoting compaction and folding transitions.

Evolutionary constraints in regulatory networks defined by partial order between phenotypes

This study identifies evolutionary constraints in regulatory networks using partial order between phenotypes and validates predictions through experimental evolution in multiple environments.

Long-term expanding human airway organoids for disease modelling.

This study establishes long-term-expanding human airway organoids from broncho-alveolar biopsies or lavage material, enabling disease modeling of cystic fibrosis, lung cancer, and RSV infection.