Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue disease
V. V. Costa, M. A. Sugimoto, J. Hubner, C. S. Bonilha, C. M. Queiroz-Junior, M. H. Goncalves-Pereira, J. Chen, T. Gobbetti, G. O. Libanio Rodrigues, J. L. Bambirra, I. B. Passos, C. E. Machado Lopes, T. P. Moreira, K. Bonjour, R. C. N. Melo, , M. M. Teixeira
This study identifies reduced Annexin A1 levels in dengue patients and mice, showing that AnxA1 agonists reduce disease severity by modulating mast cell degranulation.
bioRxiv · Nov 2, 2021Microbiology