M. M. Williams

Sarcomeric SRX:DRX Equilibrium in Alport and LDLR/P407 Mouse Models of HFpEF.

The paper quantifies SRX and DRX myosin states in HFpEF mouse models, finding altered SRX:DRX proportions linked to specific cardiac phenotypes.

NPC1 confers metabolic flexibility in Triple Negative Breast Cancer

This study identifies NPC1 as a key driver of metabolic flexibility and aggressiveness in TNBC, showing its role in cholesterol homeostasis and therapeutic vulnerability.

Genomic surveillance and improved molecular typing of Bordetella pertussis using wgMLST

This paper develops a whole-genome MLST (wgMLST) scheme for Bordetella pertussis to improve molecular typing and genomic surveillance, revealing greater resolution in population structure and outbreak analysis.

Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and through secondary effects

This study shows that ER mutations in breast cancer cells cause gene expression changes through constant activity and secondary effects, not just ligand independence.

Duplications drive diversity in Bordetella pertussis on an underestimated scale.

This study identifies widespread tandem duplications in B. pertussis genomes using read depth analysis, revealing 272 putative duplications across 11 hotspots and highlighting genome instability.

Soil microbial communities in diverse agroecosystems exposed to glyphosate

This study examines the impact of glyphosate on soil microbial communities across diverse agroecosystems and finds no significant effect after accounting for environmental and agricultural factors.