Author

I. MacArthur

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 3 Microbiology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 5 Approach:experimental assay· 4 Assay:whole-genome sequencing· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Kentsis· 3 shared A. Henssen· 2 shared A. Preston· 2 shared C. Reed· 2 shared E. de Stanchina· 2 shared E. Jiang· 2 shared E. Mullen· 2 shared E. Perlman· 2 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. Kentsis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Duplications drive diversity in Bordetella pertussis on an underestimated scale.

J. S. Abrahams, M. R. Weigand, N. A. Ring, I. MacArthur, S. Peng, M. M. Williams, B. Bready, A. P. Catalano, J. R. Davis, M. D. Kaiser, J. Oliver, J. M. Sage, S. Bagby, M. L. Tondella, A. R. Gorringe, A. Preston

This study identifies widespread tandem duplications in B. pertussis genomes using read depth analysis, revealing 272 putative duplications across 11 hotspots and highlighting genome instability.

bioRxiv · Feb 6, 2020 · PreprintMicrobiology

A qPCR assay for Bordetella pertussis cells that enumerates both live and dead bacteria.

S. Ramkissoon, I. MacArthur, M. Ibrahim, H. de Graaf, R. Read, A. Preston

The paper develops a qPCR assay to quantify both live and dead Bordetella pertussis bacteria in human challenge model samples.

bioRxiv · Sep 25, 2019Microbiology

Prohibitin is a prognostic marker of relapse and therapeutic target to block chemotherapy resistance in Wilms tumor

M. V. Ortiz, S. Ahmed, M. Burns, A. G. Henssen, T. Hollmann, I. MacArthur, S. Gunasekerea, L. Gaewsky, G. Bradwin, J. Ryan, A. Letai, Y. He, A. Naranjo, Y.-Y. Chi, M. LaQuaglia, , A. Kentsis

This study identifies prohibitin as a urine biomarker for Wilms tumor relapse and shows it promotes chemotherapy resistance by disrupting mitochondrial apoptosis.

bioRxiv · Dec 30, 2018Cancer Biology

Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors

A. Henssen, C. Reed, E. Jiang, H. D. Garcia, J. von Stebut, I. MacArthur, P. Hundsdoerfer, J. Hyun Kim, E. de Stanchina, Y. Kuwahara, H. Hosoi, N. Ganem, F. Dela Cruz, A. Kung, J. Schulte, , A. Kentsis

This study identifies PGBD5 as a therapeutic target in pediatric solid tumors, showing that inhibiting DNA repair pathways with AZD6738 sensitizes these tumors to apoptosis.

bioRxiv · Aug 25, 2017Cancer Biology

Human PGBD5 DNA transposase promotes site-specific oncogenic mutations in rhabdoid tumors

A. Henssen, R. Koche, J. Zhuang, E. Jiang, C. Reed, A. Eisenberg, E. Still, I. MacArthur, E. Rodriguez-Fos, S. Gonzalez, M. Puiggros, A. Blackford, C. Mason, E. De Stanchina, M. Gonen, , A. Kentsis

This study identifies PGBD5 as an oncogenic DNA transposase in rhabdoid tumors, causing site-specific genomic rearrangements through PSS sequences and end-joining repair.

bioRxiv · Feb 23, 2017Cancer Biology