S. Arnesen

Estrogen receptor alpha mutations regulate gene expression and cell growth in breast cancer through microRNAs

Allele-specific gene regulation, phenotypes, and therapeutic vulnerabilities in estrogen receptor alpha mutant endometrial cancer

This study investigates ER mutations in endometrial cancer, showing they alter gene expression and promote cancer phenotypes, and identifies potential therapeutic targets.

Hotspot ESR1 mutations are multimodal and contextual drivers of breast cancer metastasis

This study identifies ESR1 mutations as drivers of breast cancer metastasis by altering cell adhesion and migration through genomic and transcriptomic reprogramming.

Estrogen receptor alpha mutations in breast cancer cells cause gene expression changes through constant activity and through secondary effects

This study shows that ER mutations in breast cancer cells cause gene expression changes through constant activity and secondary effects, not just ligand independence.

Estrogen-independent molecular actions of mutant estrogen receptor alpha in endometrial cancer

This study investigates estrogen-independent actions of the D538G ESR1 mutation in endometrial cancer, showing altered genomic binding, gene expression, and chromatin accessibility compared to wildtype ESR1.