Author

I. Kurtz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Approach:statistical model· 2 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

L. Kao· 3 shared R. Azimov· 3 shared A. J. Aldave· 2 shared D. D. Chung· 2 shared E. M. Hanser· 2 shared M. Morselli· 2 shared P. M. Boere· 2 shared R. F. Frausto· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

L. Kao

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Coarse-grained molecular dynamics simulations of lipid-protein interactions in SLC4 proteins

H. R. Zhekova, D. P. Ramirez-Echemendia, B. I. Sejdiu, A. Pushkin, D. P. Tieleman, I. Kurtz

This study uses coarse-grained molecular dynamics simulations to analyze lipid-protein interactions in three SLC4 proteins, identifying potential lipid binding sites and their roles in transport function and conformational changes.

bioRxiv · Jun 26, 2023 · PreprintBiophysics

Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain

K. Kiianitsa, I. Kurtz, N. Beeman, M. Matsushita, W.-M. Chien, W. H. Raskind, O. Korvatska

The paper identifies a novel TREM2 splice isoform lacking the V-set immunoglobulin domain, which is expressed in the human brain and may affect TREM2 receptor function.

bioRxiv · Nov 30, 2020Immunology

Energy Shortage in Human and Mouse Models of SLC4A11-associated Corneal Endothelial Dystrophies

W. Zhang, R. Frausto, D. Chung, C. G. Griffis, L. Kao, A. Chen, R. Azimov, A. Sampath, I. Kurtz, A. Aldave

This study identifies metabolic dysfunction and mitochondrial impairment in SLC4A11-deficient corneal endothelial cells as the cause of dystrophy.

bioRxiv · Aug 13, 2020Cell Biology

Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion

R. F. Frausto, V. S. Swamy, G. S. Peh, P. M. Boere, E. M. Hanser, D. D. Chung, B. L. George, M. Morselli, L. Kao, R. Azimov, J. Wu, M. Pellegrini, I. Kurtz, J. S. Mehta, A. J. Aldave

This study compares two methods for expanding human corneal endothelial cells in vitro, finding that low mitogenic conditions better preserve cell identity and that senescence occurs with continuous passaging.

bioRxiv · Sep 4, 2019Cell Biology

ZEB1 insufficiency causes corneal endothelial cell state transition and altered cellular processing

R. F. Frausto, D. D. Chung, P. M. Boere, V. S. Swamy, H. N. V. Duong, L. Kao, R. Azimov, W. Zhang, L. Carrigan, D. Wong, M. Morselli, M. Zakharevich, E. M. Hanser, A. C. Kassels, I. Kurtz, , A. J. Aldave

This study shows that ZEB1 insufficiency in corneal endothelial cells leads to a MET-like transition, altering cellular phenotype and transcriptomic profile in a model of PPCD.

bioRxiv · Feb 12, 2019Cell Biology