In macrophages fatty acid oxidation spares glutamate for use in diverse metabolic pathways required for alternative activation
N. van Teijlingen Bakker, L. Flachsmann, G. E. Carrizo, D. E. Sanin, S. Lawless, A. Castoldi, L. Monteiro, A. M. Kabat, M. Matsushita, F. Haessler, A. Patterson, R. Klein Geltink, D. O'Sullivan, E. L. Pearce, E. J. Pearce
This study shows that fatty acid oxidation in macrophages supports alternative activation by maintaining glutamate levels, and that glutamine metabolism compensates for FAO disruption.
bioRxiv · Apr 13, 2022 · PreprintImmunology