Author

M. Morotti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Assay:scRNA-seq· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Research Focus:clustering· 2 Approach:deep learning· 2

Frequent Co-Authors

D. Barras· 2 shared D. Dangaj Laniti· 2 shared E. Ghisoni· 2 shared F. Benedetti· 2 shared G. Coukos· 2 shared J. Dagher· 2 shared M. Bassani-Sternberg· 2 shared N. Fahr· 2 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

D. Barras

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Myeloid cell networks determine reinstatement of original immune environments in recurrent ovarian cancer

E. Ghisoni, F. Benedetti, A. Minasyan, P. Cunnea, A. J. Grimm, N. Fahr, M. Desbuisson, C. Capt, N. Rayroux, D. C. Gulhan, J. Dagher, D. Barras, M. Morotti, J. A. Marin Jimenez, F. De Carlo, , D. Dangaj Laniti

The paper identifies immune phenotypes and myeloid cell networks in recurrent ovarian cancer that influence prognosis and immune environment reinstatement.

bioRxiv · May 2, 2024 · PreprintImmunology

Tumor Microenvironment Cellular Crosstalk Predicts Response to Adoptive TIL Therapy in Melanoma

D. Barras, E. Ghisoni, J. Chiffelle, A. Orcurto, J. Dagher, N. Fahr, F. Benedetti, I. Crespo, S. Zimmermann, R. Duran, M. Imbimbo, M. Ochoa De Olza, B. Navarro, K. Homiscko, S. Bobisse, , G. Coukos

This study identifies CD8+ TIL-myeloid cell networks as predictors of response to adoptive TIL therapy in melanoma using single-cell RNA-seq and spatial proteomic analyses.

bioRxiv · Dec 23, 2022 · PreprintImmunology

The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells

Z. Hu, M. Artibani, A. Alsaadi, N. Wietek, M. Morotti, L. Santana Gonzalez, S. El-Sahhar, M. KaramiNejadRanjbar, G. Mallett, T. Shi, K. Masuda, Y. Zheng, K. Chong, S. Damato, S. Dhar, , A. A. Ahmed

The paper uses single-cell sequencing to identify non-genetic heterogeneity in serous ovarian cancer by analyzing normal fallopian tube epithelial cells and their subtype signatures.

bioRxiv · Jun 17, 2019Cancer Biology

Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine-resistance in breast cancer

M. Morotti, E. Bridges, A. Valli, H. Choudhry, H. Sheldon, S. Wigfield, N. Gray, D. Jones, E. J. Teoh, W.-C. Cheng, S. Lord, S. Haider, A. Mcintyre, D. C. I. Goberdhan, F. Buffa, A. L. Harris

This study shows hypoxia shifts SNAT2 regulation from ER to HIF-1 in breast cancer, leading to endocrine resistance and poor outcomes.

bioRxiv · Aug 3, 2018Cancer Biology