Author

I. Crespo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Cancer Biology· 1 Immunology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cell-cell communication· 3 Research Focus:differential expression· 3 Organism:human· 3 Organism:mouse· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

G. Coukos· 3 shared A. Harari· 2 shared A. Orcurto· 2 shared D. Barras· 2 shared D. Dangaj Laniti· 2 shared E. Ghisoni· 2 shared F. Benedetti· 2 shared J. Chiffelle· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

G. Coukos

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Acidity-induced dysfunction of CD8+ T cells is characterized by impaired IL-2 responsiveness and perturbations to mTORC1 signaling and c-Myc levels

R. Vuillefroy de Silly, L. Pericou, B. Seijo, I. Crespo, G. Coukos, M. Irving

This study shows that low pH impairs CD8+ T cell function by reducing IL-2 responsiveness, disrupting mTORC1 signaling, and altering c-Myc levels and amino acid metabolism.

bioRxiv · Dec 15, 2023Cell Biology

Tumor-reactive clonotype dynamics underlying clinical response to TIL therapy in melanoma

J. Chiffelle, D. Barras, R. Petremand, A. Orcurto, S. Bobisse, M. Arnaud, A. Auger, B. Navarro Rodrigo, E. Ghisoni, C. Sauvage, D. Saugy, A. Michel, B. Murgues, N. Fahr, M. Imbimbo, , G. Coukos

This study tracks tumor-reactive TIL clonotypes in melanoma patients before and after TIL-ACT to identify factors associated with clinical response.

bioRxiv · Jul 21, 2023 · PreprintCancer Biology

Tumor Microenvironment Cellular Crosstalk Predicts Response to Adoptive TIL Therapy in Melanoma

D. Barras, E. Ghisoni, J. Chiffelle, A. Orcurto, J. Dagher, N. Fahr, F. Benedetti, I. Crespo, S. Zimmermann, R. Duran, M. Imbimbo, M. Ochoa De Olza, B. Navarro, K. Homiscko, S. Bobisse, , G. Coukos

This study identifies CD8+ TIL-myeloid cell networks as predictors of response to adoptive TIL therapy in melanoma using single-cell RNA-seq and spatial proteomic analyses.

bioRxiv · Dec 23, 2022 · PreprintImmunology

Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation

J. Blazquez-Prieto, C. Huidobro, I. Lopez-Alonso, L. Amado-Rodriguez, P. Martin-Vicente, C. Lopez-Martinez, I. Crespo, C. Pantoja, P. J. Fernandez-Marcos, M. Serrano, J. I. Sznajder, G. M. Albaiceta

This study shows that activation of the p53/p21 pathway limits acute lung injury by reducing cell apoptosis but also induces early senescence in alveolar cells.

Translational Research · Jul 1, 2021Peer-reviewedCell Biology

Design principles of a minimal auxin response system

H. Kato, S. Mutte, H. Suzuki, I. Crespo, S. Das, T. Radoeva, M. Fontana, Y. Yoshitake, E. Hainiwa, W. van den Berg, S. Lindhoud, J. Hohlbein, J. W. Borst, R. Boer, R. Nishihama, , D. Weijers

The paper identifies a minimal auxin response system in Marchantia polymorpha, showing that a single A-ARF activates gene expression while a B-ARF represses it, defining developmental zones of auxin response.

bioRxiv · Sep 8, 2019Plant Biology