Author

M. N. Hui

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. S. Cazet· 3 shared A. Swarbrick· 3 shared C.-L. Chan· 3 shared E. Lim· 3 shared K. Harvey· 3 shared S. O'Toole· 3 shared S. Z. Wu· 3 shared C. Cooper· 2 shared

Activity by Year

2017-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. S. Cazet

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Author profile →

3 papers

Recent·Most cited

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

S. Z. Wu, D. L. Roden, C. Wang, H. Holliday, K. Harvey, A. S. Cazet, K. J. Murphy, B. Pereira, G. Al-Eryani, N. Bartonicek, R. Hou, J. R. Torpy, S. Junankar, C.-L. Chan, E. Lam, , A. Swarbrick

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

bioRxiv · Jun 4, 2020Cancer Biology

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

S. Z. Wu, D. L. Roden, G. Al-Eryani, N. Bartonicek, K. Harvey, A. S. Cazet, C.-L. Chan, S. Junankar, M. N. Hui, E. Millar, J. Beretov, L. Horvath, A. M. Joshua, P. Stricker, J. S. Wilmott, , A. Swarbrick

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.

bioRxiv · Jun 4, 2020Cancer Biology

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

A. S. Cazet, M. N. Hui, B. L. Elsworth, S. Z. Wu, D. Roden, C.-L. Chan, J. N. Skhinas, R. Collot, J. Yang, K. Harvey, M. Z. Johan, C. Cooper, R. Nair, D. Herrmann, A. McFarland, , A. Swarbrick

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.

bioRxiv · Nov 8, 2017Cancer Biology