Author

C.-L. Chan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 8 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 8 Research Focus:cell type annotation· 6 Research Focus:differential expression· 5 Assay:bulk RNA-seq· 4 Research Focus:gene regulatory network inference· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4

Frequent Co-Authors

A. Swarbrick· 8 shared K. Harvey· 6 shared D. L. Roden· 5 shared G. Al-Eryani· 5 shared J. Yang· 5 shared N. Bartonicek· 5 shared S. Junankar· 5 shared S. Z. Wu· 5 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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8 shared papersCancer Biology

A. Swarbrick

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

An experimental comparison of the Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research

T. Wang, K. Harvey, J. Reeves, D. L. Roden, N. Bartonicek, J. Yang, G. Al-Eryani, D. Kaczorowski, C.-L. Chan, J. Powell, S. O'Toole, E. Lim, A. Swarbrick

This study compares Digital Spatial Profiling and Visium spatial transcriptomics technologies for cancer research, finding differences in sensitivity, specificity, and application suitability.

bioRxiv · Apr 6, 2023 · PreprintCancer Biology

Integration of single-cell RNA and protein data identifies novel clinically-relevant lymphocyte phenotypes in breast cancers

G. Al-Eryani, N. Bartonicek, C.-L. Chan, A. Anderson, K. Harvey, S. Z. Wu, D. Roden, T. Wang, J. Reeves, B. Z. Yeung, E. Masle-Farquhar, C. C. Goodnow, C. Ma, T. G. Phan, J. Lundeberg, , A. Swarbrick

The paper integrates single-cell RNA and protein data from breast cancer samples to identify novel lymphocyte phenotypes and their clinical relevance.

bioRxiv · May 31, 2022 · PreprintImmunology

DNA barcoding reveals ongoing immunoediting of clonal cancer populations during metastatic progression and in response to immunotherapy

L. A. Baldwin, N. Bartonicek, J. Yang, S. Z. Wu, N. Deng, D. L. Roden, C.-L. Chan, G. Al-Eryani, D. J. Zanker, B. S. Parker, A. Swarbrick, S. Junankar

This study uses DNA barcoding to track clonal evolution in breast cancer during metastasis and immunotherapy, finding ongoing immunoediting and identifying potential therapeutic targets.

bioRxiv · Jan 11, 2021Cancer Biology

A Single-Cell Tumor Immune Atlas for Precision Oncology

P. Nieto, M. Marc Elosua-Bayes, J. L. Trincado, D. Marchese, R. Massoni-Badosa, M. Salvany, A. Henriques, E. Mereu, C. Moutinho, S. Ruiz, P. Lorden, V. Chin, D. C. Kaczorowski, C.-L. Chan, R. Gallagher, , H. Heyn

The paper creates a single-cell tumor immune atlas using data from 217 patients and 13 cancer types to improve immune cell annotation and spatial mapping for precision oncology.

bioRxiv · Oct 26, 2020Cancer Biology

Single-cell analysis reveals diverse stromal subsets associated with immune evasion in triple-negative breast cancer

S. Z. Wu, D. L. Roden, C. Wang, H. Holliday, K. Harvey, A. S. Cazet, K. J. Murphy, B. Pereira, G. Al-Eryani, N. Bartonicek, R. Hou, J. R. Torpy, S. Junankar, C.-L. Chan, E. Lam, , A. Swarbrick

This study identifies diverse stromal subsets in TNBC using single-cell RNA-seq and links them to immune evasion mechanisms and therapeutic targets.

bioRxiv · Jun 4, 2020Cancer Biology

Cryopreservation of human cancers conserves tumour heterogeneity for single-cell multi-omics analysis

S. Z. Wu, D. L. Roden, G. Al-Eryani, N. Bartonicek, K. Harvey, A. S. Cazet, C.-L. Chan, S. Junankar, M. N. Hui, E. Millar, J. Beretov, L. Horvath, A. M. Joshua, P. Stricker, J. S. Wilmott, , A. Swarbrick

This study shows that cryopreservation of human cancers preserves tumour heterogeneity for single-cell multi-omics analysis, with comparable results to fresh tissue.

bioRxiv · Jun 4, 2020Cancer Biology

Id proteins promote a cancer stem cell phenotype in triple negative breast cancer via negative regulation of Robo1

W. S. Teo, H. Holliday, N. Karthikeyan, A. S. Cazet, D. L. Roden, K. Harvey, C. V. Konrad, R. Murali, B. A. Varghese, A. P. T., C.-L. Chan, A. McFarland, S. Junankar, S. Ye, J. Yang, , R. Nair

This study shows that Id proteins promote a cancer stem cell phenotype in triple negative breast cancer by negatively regulating Robo1, leading to Myc activation.

bioRxiv · Mar 11, 2020 · PreprintCancer Biology

MicroRNAs as potential therapeutics to enhance chemosensitivity in advancedprostate cancer

H.-M. Lin, I. Nikolic, J. Yang, L. Castillo, N. Deng, C.-L. Chan, N. K. Yeung, E. Dodson, B. Elsworth, C. Spielman, B. Lee, Z. Boyer, K. Simpson, R. J. Daly, L. G. Horvath, A. Swarbrick

This study identifies microRNA mimics that enhance taxane-induced apoptosis in CRPC cell lines, suggesting potential therapeutic use to improve chemosensitivity.

bioRxiv · Feb 28, 2018Cancer Biology

Targeting stromal remodeling and cancer stem cell plasticity to overcome chemoresistance in triple negative breast cancer

A. S. Cazet, M. N. Hui, B. L. Elsworth, S. Z. Wu, D. Roden, C.-L. Chan, J. N. Skhinas, R. Collot, J. Yang, K. Harvey, M. Z. Johan, C. Cooper, R. Nair, D. Herrmann, A. McFarland, , A. Swarbrick

This study identifies Hedgehog signaling to cancer-associated fibroblasts as a driver of cancer stem cell plasticity and chemoresistance in TNBC, showing that targeting this pathway with smoothened inhibitors improves survival in preclinical models and clinical trials.

bioRxiv · Nov 8, 2017Cancer Biology