Mechanism of degrader-targeted protein ubiquitinability
C. Crowe, M. Nakasone, S. Chandler, M. H. Tatham, N. Makukhin, R. T. Hay, A. Ciulli
The paper solves cryo-EM structures of a degrader-mediated complex to reveal structural insights into target protein ubiquitination mechanisms.
bioRxiv · Feb 5, 2024Biochemistry