The HIV-1 Integrase C-Terminal domain induces TAR RNA structural changes promoting Tat binding.
C. Rocchi, C. Louvat, A. E. Miele, J. Batisse, C. Guillon, L. Ballut, D. Lener, M. Negroni, M. Ruff, P. Gouet, F. Fiorini
This study shows that the HIV-1 Integrase C-terminal domain interacts with TAR RNA, inducing structural changes that facilitate Tat binding and displace IN from TAR.
bioRxiv · Oct 21, 2021Biochemistry