Author

J. Batisse

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. Ruff· 3 shared A. Cimarelli· 1 shared A. E. Miele· 1 shared A. Valenzuela-Fernandez· 1 shared B. Ledoussal· 1 shared B. Stupfler· 1 shared C. Amadori· 1 shared C. Batisse· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersMicrobiology

M. Ruff

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors

E. Le Rouzic, D. Bonnard, F. Le Strat, C. Batisse, J. Batisse, C. Amadori, S. Chasset, S. Emiliani, B. Ledoussal, M. Ruff, F. Moreau, R. Benarous

This paper describes a new class of HIV-1 integrase-LEDGF allosteric inhibitors with potent anti-HIV activity, resistance to existing drugs, and a lead compound validated in a phase I trial.

bioRxiv · Jan 28, 2023 · PreprintMicrobiology

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, S. Sousa, M. Metifiot, P. Weigel, K. Yamatsugu, M. Kanai, H. Lehmann, C. Richetta, J. Batisse, M. Ruff, O. Delelis, , V. Parissi

The paper develops an alphaLISA assay to study intasome-nucleosome interactions, identifies compounds that modulate this interaction, and shows their antiviral effects against PFV and HIV-1.

bioRxiv · Sep 29, 2022Microbiology

The HIV-1 Integrase C-Terminal domain induces TAR RNA structural changes promoting Tat binding.

C. Rocchi, C. Louvat, A. E. Miele, J. Batisse, C. Guillon, L. Ballut, D. Lener, M. Negroni, M. Ruff, P. Gouet, F. Fiorini

This study shows that the HIV-1 Integrase C-terminal domain interacts with TAR RNA, inducing structural changes that facilitate Tat binding and displace IN from TAR.

bioRxiv · Oct 21, 2021Biochemistry

A conserved uORF regulates APOBEC3G translation and is targeted by HIV-1 Vif protein to repress the antiviral factor

C. Libre, T. Seissler, S. Guerrero, J. Batisse, C. Verriez, B. Stupfler, O. Gilmer, R. Cabrera-Rodriguez, M. M. Weber, A. Valenzuela-Fernandez, A. Cimarelli, L. Etienne, R. Marquet, J.-C. Paillart

The paper identifies a conserved upstream ORF (uORF) in APOBEC3G mRNA that regulates its translation and is targeted by HIV-1 Vif to suppress antiviral activity.

bioRxiv · Jan 13, 2021Microbiology