F. Fiorini

The SARS-CoV-2 nucleocapsid protein inhibits the cellular Nonsense-Mediated mRNA Decay (NMD) pathway preventing the full enzymatic activation of UPF1.

This study shows that SARS-CoV-2 Np inhibits NMD by blocking UPF1 activity and disrupting UPF1/UPF2 complex formation, revealing a novel mechanism of viral evasion.

Stable Structures or poly(A)-binding protein loading protect cellular and viral RNAs against ISG20-mediated decay

The paper identifies PABP1 loading and terminal stem-loop structures as factors protecting RNAs from ISG20-mediated decay, with implications for both cellular and viral RNAs.

The inflammatory and tumor suppressor SAMD9L acts through a Schlafen-like box to restrict HIV and inhibit cell translation in SAAD/ATXPC

This paper identifies SAMD9L as an HIV-1 restriction factor that inhibits viral and cellular translation through a Schlafen-like box, with implications for HIV/AIDS and genetic diseases.

The HIV-1 Integrase C-Terminal domain induces TAR RNA structural changes promoting Tat binding.

This study shows that the HIV-1 Integrase C-terminal domain interacts with TAR RNA, inducing structural changes that facilitate Tat binding and displace IN from TAR.