Author

M. Ruff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Organism:human· 4 Assay:ChIP-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

J. Batisse· 3 shared D. Lapaillerie· 2 shared E. Mauro· 2 shared L. Paul· 2 shared M. Metifiot· 2 shared V. Parissi· 2 shared A. E. Miele· 1 shared A. Radwanska· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

J. Batisse

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors

E. Le Rouzic, D. Bonnard, F. Le Strat, C. Batisse, J. Batisse, C. Amadori, S. Chasset, S. Emiliani, B. Ledoussal, M. Ruff, F. Moreau, R. Benarous

This paper describes a new class of HIV-1 integrase-LEDGF allosteric inhibitors with potent anti-HIV activity, resistance to existing drugs, and a lead compound validated in a phase I trial.

bioRxiv · Jan 28, 2023 · PreprintMicrobiology

Coalescent RNA-localizing and transcriptional activities of SAM68 modulate adhesion and subendothelial basement membrane assembly

Z. Rekad, M. Ruff, A. Radwanska, D. Grall, D. Ciais, E. Van Obberghen-Schilling

This study identifies SAM68 as a regulator of endothelial cell adhesion and basement membrane assembly through RNA localization and transcriptional modulation.

bioRxiv · Nov 16, 2022Cell Biology

Modulation of the functional interfaces between retroviral intasomes and the human nucleosome

E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, S. Sousa, M. Metifiot, P. Weigel, K. Yamatsugu, M. Kanai, H. Lehmann, C. Richetta, J. Batisse, M. Ruff, O. Delelis, , V. Parissi

The paper develops an alphaLISA assay to study intasome-nucleosome interactions, identifies compounds that modulate this interaction, and shows their antiviral effects against PFV and HIV-1.

bioRxiv · Sep 29, 2022Microbiology

The HIV-1 Integrase C-Terminal domain induces TAR RNA structural changes promoting Tat binding.

C. Rocchi, C. Louvat, A. E. Miele, J. Batisse, C. Guillon, L. Ballut, D. Lener, M. Negroni, M. Ruff, P. Gouet, F. Fiorini

This study shows that the HIV-1 Integrase C-terminal domain interacts with TAR RNA, inducing structural changes that facilitate Tat binding and displace IN from TAR.

bioRxiv · Oct 21, 2021Biochemistry

Analysis of the intrinsic chromatin binding property of HIV-1 integrase and its regulation by LEDGF/p75 using human chromosomes spreads

D. Lapaillerie, E. Mauro, B. Lelandais, G. Ferran, N. Kuschner, C. Calmels, M. Metifiot, C. Rooryck, M. Ruff, C. Zimmer, L. Paul, J. Toutain, V. Parissi

This study investigates the chromatin-binding properties of HIV-1 integrase and its regulation by LEDGF/p75 using biochemical and chromosome-binding assays.

bioRxiv · Dec 23, 2020 · PreprintMicrobiology