Hsp multichaperone complex buffers pathologically modified Tau
A. Moll, L.-M. Ramirez, M. Ninov, J. Schwarz, H. Urlaub, M. Zweckstetter
This study identifies the Hsp70/Hsp90 multichaperone complex as a critical regulator of Tau by stabilizing it and preventing aggregation, with p23 enhancing complex formation and CHIP facilitating degradation.
bioRxiv · Mar 18, 2022Biophysics