J. Schwarz

SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses

This study shows that SCCA1/SERPINB3 promotes an immunosuppressive tumor microenvironment by increasing chemokine production via STAT signaling, reducing T cell responses to radiotherapy.

Transcription regulates bleb formation and stability independent of nuclear rigidity

This study shows transcription affects nuclear bleb formation and stability independently of chromatin structure or nuclear rigidity.

New motifs in Ndc1 mediating interaction with the Nup84 complex and nuclear membranes

This study identifies new motifs in Ndc1 that mediate its interaction with the Nup84 complex and nuclear membranes, revealing their role in NPC biogenesis.

Hsp multichaperone complex buffers pathologically modified Tau

This study identifies the Hsp70/Hsp90 multichaperone complex as a critical regulator of Tau by stabilizing it and preventing aggregation, with p23 enhancing complex formation and CHIP facilitating degradation.

Sinking the way: a dual role for CCR7 in collective leukocyte migration

This study shows CCR7 has a dual role in leukocyte migration by both sensing and consuming its ligand to generate and modulate chemotactic gradients.

Quantitative Proteomics Identifies PTP1B as Modulator of B Cell Antigen Receptor Signaling

The paper identifies PTP1B as a negative regulator of B cell antigen receptor signaling by dephosphorylating key receptor and downstream signaling components.

The role of vimentin-nuclear interactions in persistent cell motility through confined spaces

This paper develops a model showing vimentin-null cells move faster and are more persistent in confined spaces due to reduced nuclear positioning and microtubule orientation.

Exploring the upper pH limits of nitrite oxidation: diversity, ecophysiology, and adaptive traits of haloalkalitolerant Nitrospira

This study identifies haloalkalitolerant Nitrospira species in extreme pH lakes, revealing their diversity and adaptive traits for nitrite oxidation at high pH.