C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition
Victoria J. Butler, Wilian Augusto Cortopassi, Andrea R. Argouarch, M. Olivia Pierce, Mihir Vohra, Juan A. Osés-Prieto, Fuying Gao, Benjamin Caballero, Shreya Chand, William W. Seeley, Bruce L. Miller, Giovanni Coppola, Alma L. Burlingame, Kaveh Ashrafi, Ana María Cuervo, , Aimee W. Kao
This study identifies granulins as regulators of lysosomal protease activity in C. elegans, showing their role in age-related protein homeostasis decline.
bioRxiv · Nov 17, 2018 · PreprintNeuroscience