Juan A. Osés-Prieto

This study identifies Paralemmin 2 as a lipid raft-associated protein that regulates axon initial segments and paranodal junctions through cell type-specific splicing.

The paper develops a method to profile synaptic proteomes under physiological conditions and identifies EGFR signaling as a key activity-dependent process at synapses.

This study compares synaptic vesicle protein composition between dopamine and glutamate release sites, identifying differences in abundance and function that affect recycling kinetics.

The paper identifies myelin basic protein (MBP) as an RNA chaperone that facilitates microglial nuclear import of myelin RNA, with implications for multiple sclerosis pathology.

This study investigates the roles of PlexinA2, PlexinA4, and NCAM in the development of mossy fibers in the hippocampus, revealing distinct and overlapping functions in axon bundling and targeting.

This study shows that acetylation of G3BP1 by ELP3 promotes axon regeneration and neuronal recovery after injury.

The paper shows class I HDACs can catalyze beta-hydroxybutyrylation of lysine, a reversible modification, expanding the role of HDACs beyond traditional deacetylation.

The paper identifies RBM42 as a key regulator of MYC translation in PDAC, showing its role in oncogenic transcript regulation and tumor growth.

The paper identifies TAOK2 as a regulator of primary cilium length in 16p11.2 CNV carriers, showing opposing effects in deletion and duplication cases.

RAPIDASH enriches ribosome-associated proteins from diverse samples, revealing their roles in neurodevelopment and immune response.

This study identifies NEK1's role in motor neuron neurite outgrowth by coordinating retromer formation through interactions with SMC3.

The paper identifies Contactin-1 as an AIS cell surface protein that regulates axo-axonic innervation by interacting with Neurofascin and NrCAM.

This study uses CRISPR-Cas9 base editing to target the human spliceosome and identifies functional sites and resistance substitutions, revealing SUGP1's role in spliceosome disassembly.

This paper develops a novel anti-KPNB1 monoclonal antibody for BAR analysis, revealing new importin β1 interactors and expanding its known functions beyond nucleocytoplasmic transport.

This study identifies KHSRP as an axonal RNA-binding protein whose mRNA is locally translated after nerve injury, leading to mRNA destabilization and slowed axon regeneration.

The paper isolates and characterizes AMPA receptor trafficking vesicles from mouse brains, identifying known and novel proteins involved in their composition and function in synaptic plasticity.

This study identifies AnkR's role in regulating fast-spiking interneuron excitability through perineuronal nets and Kv3.1b K+ channels in mouse and human.

This study identifies AtACINUS as an O-GlcNAcylated and O-fucosylated protein that regulates transcription and alternative splicing of reproductive regulators in Arabidopsis.

This study identifies granulins as regulators of lysosomal protease activity in C. elegans, showing their role in age-related protein homeostasis decline.

The paper shows that translation directly regulates chromatin state and transcription in ES cells, with reduced translation causing rapid chromatin changes.