Kaveh Ashrafi

Dietary restriction promotes neuronal resilience via ADIOL

This paper identifies ADIOL as a mediator of dietary restriction's healthspan benefits, showing it improves aging indicators without extending lifespan.

C. elegans granulins promote an age-associated decline in protein homeostasis via lysosomal protease inhibition

This study identifies granulins as regulators of lysosomal protease activity in C. elegans, showing their role in age-related protein homeostasis decline.

Rescue of a developmental arrest caused by a C. elegans heat-shock transcription-factor mutation by loss of ribosomal S6-kinase activity

This study identifies that loss of rsks-1/S6-Kinase rescues developmental arrest in C. elegans hsf-1 mutants, revealing an unexplained regulatory link between heat-shock transcription factors and the TOR pathway during development.