SCOPE: Flexible targeting and stringent CARF activation enables type III CRISPR-Cas diagnostics
J. A. Steens, Y. Zhu, D. W. Taylor, J. P. K. Bravo, S. H. P. Prinsen, C. D. Schoen, B. J. F. Keijser, M. Ossendrijver, L. M. Hofstra, S. J. J. Brouns, A. Shinkai, J. van der Oost, R. H. J. Staals
This study identifies key regions in type III CRISPR-Cas systems for RNA targeting and cOA production, leading to the development of the SCOPE diagnostic tool for SARS-CoV-2 detection.
Nature Communications · Aug 19, 2021Peer-reviewedBiochemistry