MCL1 dependence across MDS subtypes and dual inhibition of MCL1 and BCL2 in MISTRG6 mice
M. A. Fischer, Y. Song, R. Gbyli, M. P. Arrate, M. T. Villaume, M. A. Childress, B. N. Smith, T. P. Stricker, S. Halene, M. R. Savona
The paper assesses MCL1 dependence in MDS subtypes and shows that combined inhibition of BCL2 and MCL1 is synergistic in vitro and reduces MDS engraftment in mice.
bioRxiv · Jun 5, 2020 · PreprintCancer Biology