Author

M. P. Machner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Simeonov· 1 shared A. Zakharov· 1 shared B. Kim· 1 shared C. L. Larson· 1 shared D. Dorjsuren· 1 shared E. Cheng· 1 shared G. Rai· 1 shared H. Sun· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperMicrobiology

A. Simeonov

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2 papers

Recent·Most cited

A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial Type IVB secretion system

E. Cheng, D. Dorjsuren, S. S. Lehman, C. L. Larson, S. Titus, H. Sun, A. Zakharov, G. Rai, R. A. Heinzen, A. Simeonov, M. P. Machner

This paper identifies compounds that inhibit T4SS-mediated effector delivery in pathogens, offering potential for pathogen-specific therapeutics.

mBio · Apr 26, 2022Peer-reviewedMicrobiology

A multiplex CRISPR interference tool for virulence gene interrogation in an intracellular pathogen

N. A. Ellis, B. Kim, M. P. Machner

This paper develops a multiplex CRISPRi platform in Legionella pneumophila to silence up to ten virulence genes simultaneously, demonstrating its effectiveness in both axenic growth and macrophage infection.

bioRxiv · Jun 17, 2020Microbiology