Author

S. S. Lehman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Simeonov· 1 shared A. Zakharov· 1 shared C. L. Larson· 1 shared C. M. Pike· 1 shared C. Williamson· 1 shared D. Dorjsuren· 1 shared E. Cheng· 1 shared G. Rai· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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1 shared paperMicrobiology

A. Simeonov

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Author profile →

3 papers

Recent·Most cited

Metagenome diversity illuminates origins of pathogen effectors

V. I. Verhoeve, S. S. Lehman, T. P. Driscoll, J. F. Beckmann, J. J. Gillespie

The paper uses metagenome assembled genomes to study the origins and evolution of Rickettsia rvh effectors, revealing gene duplication, recombination, and lateral gene transfer as key drivers of effector diversity.

bioRxiv · Feb 26, 2023 · PreprintMicrobiology

A comprehensive phenotypic screening strategy to identify modulators of cargo translocation by the bacterial Type IVB secretion system

E. Cheng, D. Dorjsuren, S. S. Lehman, C. L. Larson, S. Titus, H. Sun, A. Zakharov, G. Rai, R. A. Heinzen, A. Simeonov, M. P. Machner

This paper identifies compounds that inhibit T4SS-mediated effector delivery in pathogens, offering potential for pathogen-specific therapeutics.

mBio · Apr 26, 2022Peer-reviewedMicrobiology

Legionella pneumophila targets autophagosomes and promotes host autophagy during late infection

R. R. Noll, C. M. Pike, S. S. Lehman, C. Williamson, R. Neunuebel

This study identifies Lpg2411 as an effector protein that promotes autophagy in host cells during late Legionella pneumophila infection.

bioRxiv · Jul 8, 2021 · PreprintMicrobiology