Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System
M. P. Moazami, J. M. Rembetsy-Brown, F. Wang, P. M. Krishnamurthy, A. Weiss, M. Marosfoi, R. M. King, M. Motwani, H. Gray-Edwards, K. A. Fitzgerald, R. H. Brown, J. K. Watts
This study quantifies motor phenotypes caused by ASOs in the CNS and identifies modifications that reduce toxicity while maintaining efficacy.
bioRxiv · Feb 14, 2021Pharmacology & Toxicology