Author

J. K. Watts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

E. J. Sontheimer· 2 shared A. J. Debacker· 1 shared A. Khvorova· 1 shared A. Mir· 1 shared A. Riemenschneider· 1 shared A. T. Joynt· 1 shared A. Weiss· 1 shared C. A. Schiffer· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersBiochemistry

E. J. Sontheimer

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Quantifying and Mitigating Motor Phenotypes Induced by Antisense Oligonucleotides in the Central Nervous System

M. P. Moazami, J. M. Rembetsy-Brown, F. Wang, P. M. Krishnamurthy, A. Weiss, M. Marosfoi, R. M. King, M. Motwani, H. Gray-Edwards, K. A. Fitzgerald, R. H. Brown, J. K. Watts

This study quantifies motor phenotypes caused by ASOs in the CNS and identifies modifications that reduce toxicity while maintaining efficacy.

Molecular Therapy · Dec 1, 2024Peer-reviewedPharmacology & Toxicology

Addressing the dNTP bottleneck restricting prime editing activity

K. Ponnienselvan, P. Liu, T. Nyalile, S. Oikemus, A. T. Joynt, K. Kelly, D. Guo, Z. Chen, J. M. Lee, C. A. Schiffer, C. P. Emerson, N. D. Lawson, J. K. Watts, E. J. Sontheimer, J. Luban, S. A. Wolfe

This study identifies mutations to improve prime editing efficiency in low-dNTP environments by enhancing MMLV-reverse transcriptase and reducing SAMHD1 activity.

bioRxiv · Oct 21, 2023Biochemistry

CASCADES, a novel SOX2 super-enhancer associated long noncoding RNA, regulates cancer stem cell specification and differentiation in glioblastoma multiforme

U. Shahzad, C. Li, M. Johnston, J. J. Wang, N. Sabha, F. S. Varn, A. Riemenschneider, S. Krumholtz, P. Meda, C. Smith, J. Karamchandani, J. K. Watts, R. G. W. Verhaak, M. Gallo, J. T. Rutka, S. Das

This study identifies CASCADES, a lncRNA that regulates stemness in glioblastoma cancer stem cells by epigenetically controlling SOX2 expression.

bioRxiv · Sep 5, 2020 · PreprintCancer Biology

Heavily and Fully Modified RNAs Guide Efficient SpyCas9-Mediated Genome Editing

A. Mir, J. F. Alterman, M. R. Hassler, A. J. Debacker, E. Hudgens, D. Echeverria, M. H. Brodsky, A. Khvorova, J. K. Watts, E. J. Sontheimer

This study identifies heavily and fully modified crRNA and tracrRNA that enhance Cas9-mediated genome editing efficiency and stability in human cells.

bioRxiv · Mar 28, 2018Biochemistry