BiochemistrybioRxiv
Fine-tuning GPCR-mediated neuromodulation by biasing signaling through different G-protein subunits
J.-C. Park, A. Luebbers, M. Dao…·M. Garcia-Marcos
The paper shows how GINIP biases GPCR signaling to favor Gβγ over G signaling, preventing neurotransmission imbalances and seizure susceptibility.
DOI 10.1016/j.molcel.2023.06.006