Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in mice
V. F. Monteiro-Cardoso, X. Y. Yeo, H.-G. Bae, D. Castano Mayan, M. Wehbe, S. Lee, K. Krishna-K, S. H. Baek, L. F. Palomera, S. Shanmugam, K. P. Sem, M. P. Parsons, M. R. Hayden, E. A. Liehn, S. Sajikumar, , R. R. Singaraja
This study shows that absence of CYP8B1 increases brain chenodeoxycholic acid (CDCA) levels, reducing neuronal excitotoxicity and stroke infarct area in mice.
bioRxiv · Dec 11, 2022 · PreprintPhysiology