Author

M. R. Hayden

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

A. Hill· 1 shared A. J. Cutts· 1 shared B. R. Leavitt· 1 shared C. J. Cohen· 1 shared C. Young· 1 shared D. Castano Mayan· 1 shared D.-G. Jo· 1 shared E. A. Liehn· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Hill

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Author profile →

3 papers

Recent·Most cited

Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation

A. J. Cutts, S. Chowdhury, L. Ratkay, M. Eyers, C. Young, R. Namdari, J. Cadieux, N. Chahal, M. Grimwood, Z. Zhang, S. Lin, I. Tietjen, Z. Xie, L. Robinette, L. Sojo, , C. J. Cohen

This paper identifies XEN602, a potent, gut-restricted DMT1 inhibitor, showing efficacy in reducing iron overload in rats and pigs with minimal systemic exposure.

The Journal of Pharmacology and Experimental Therapeutics · Jul 1, 2023Peer-reviewedPharmacology & Toxicology

Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in mice

V. F. Monteiro-Cardoso, X. Y. Yeo, H.-G. Bae, D. Castano Mayan, M. Wehbe, S. Lee, K. Krishna-K, S. H. Baek, L. F. Palomera, S. Shanmugam, K. P. Sem, M. P. Parsons, M. R. Hayden, E. A. Liehn, S. Sajikumar, , R. R. Singaraja

This study shows that absence of CYP8B1 increases brain chenodeoxycholic acid (CDCA) levels, reducing neuronal excitotoxicity and stroke infarct area in mice.

bioRxiv · Dec 11, 2022 · PreprintPhysiology

Huntingtin Over-Expression Does Not Alter Overall Survival in Murine Cancer Models

L. Chan, A. Hill, G. Lu, J. Van Raamsdonk, R. D. Gascoyne, M. R. Hayden, B. R. Leavitt

This study tests if mutant huntingtin protects against cancer by over-expressing it in murine cancer models, finding no effect on survival.

bioRxiv · Sep 11, 2022 · PreprintCancer Biology