The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts.
M. P. Schneider, O. Looker, M. Rebelo, D. S. Khoury, M. W. Dixon, C. Oeuvray, B. S. Crabb, J. McCarthy, P. R. Gilson
This study shows M5717 delays Plasmodium falciparum parasite clearance by preventing host RBC modification, leading to reduced cytoadherence and splenic clearance.
bioRxiv · Apr 24, 2023 · PreprintMicrobiology