Author

P. R. Gilson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Cell Biology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 9 Organism:human· 6 Assay:proteomics· 5 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Organism:plant (other)· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

B. S. Crabb· 7 shared M. G. Dans· 5 shared B. E. Sleebs· 4 shared H. E. Bullen· 4 shared O. Looker· 3 shared A. E. Barry· 2 shared C. Boulet· 2 shared D. B. Ling· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersMicrobiology

B. S. Crabb

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

M. G. Dans, C. Boulet, G. M. Watson, W. Nguyen, J. M. Dziekan, C. Evelyn, K. Reaksudsan, S. Mehra, Z. Razook, N. D. Geoghegan, M. J. Mlodzianoski, C. D. Goodman, D. B. Ling, T. K. Jonsdottir, J. Tong, , P. R. Gilson

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

bioRxiv · Nov 2, 2023 · PreprintCell Biology

A pyridyl-furan series developed from Open Global Health Library blocks red blood cell invasion and protein trafficking in Plasmodium falciparum through potential inhibition of the parasites PI4KIIIb enzyme.

D. B. Ling, W. Nguyen, O. Looker, Z. Razook, K. McCann, A. E. Barry, C. Scheurer, S. Wittlin, H. E. Bullen, B. S. Crabb, B. E. Sleebs, P. R. Gilson

The paper identifies a pyridyl-furan compound series that inhibits Plasmodium falciparum growth and red blood cell invasion by targeting the PI4KIIIb enzyme.

bioRxiv · Apr 25, 2023Microbiology

The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts.

M. P. Schneider, O. Looker, M. Rebelo, D. S. Khoury, M. W. Dixon, C. Oeuvray, B. S. Crabb, J. McCarthy, P. R. Gilson

This study shows M5717 delays Plasmodium falciparum parasite clearance by preventing host RBC modification, leading to reduced cytoadherence and splenic clearance.

bioRxiv · Apr 24, 2023 · PreprintMicrobiology

The Dual Action of Human Antibodies Specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites

G. E. Weiss, R. J. Ragotte, D. Quinkert, A. M. Lias, M. G. Dans, C. Boulet, B. G. Williams, B. S. Crabb, S. J. Draper, P. R. Gilson

This paper shows that antibodies against PfRH5 and PfCyRPA block parasite invasion and inactivate extracellular merozoites by triggering a developmental pathway normally seen after invasion.

bioRxiv · Feb 7, 2023 · PreprintMicrobiology

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum.

T. K. Jonsdottir, B. Elsworth, S. Cobbold, M. Gabriela, S. C. Charnaud, M. G. Dans, M. Parkyn Schneider, M. McConville, H. E. Bullen, B. S. Crabb, P. R. Gilson

This study identifies PTEX150 as essential for trafficking haemoglobinases to the food vacuole in Plasmodium falciparum, revealing a new metabolic function for PTEX beyond the known permeability pathway.

bioRxiv · Nov 15, 2022 · PreprintMicrobiology

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

O. Looker, M. G. Dans, H. E. Bullen, B. E. Sleebs, B. S. Crabb, P. R. Gilson

The paper screens 400 anti-malarial compounds to identify inhibitors of protein export in Plasmodium falciparum, finding MMV396797 as a potent inhibitor that reduces parasite virulence.

bioRxiv · May 1, 2022Biochemistry

Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of Plasmodium falciparum reveals several inhibitory compounds

M. G. Dans, G. E. Weiss, D. W. Wilson, B. E. Sleebs, B. Crabb, T. F. de Koning-Ward, P. R. Gilson

The paper screens a compound library to identify inhibitors of Plasmodium falciparum egress and invasion, finding several compounds with specific inhibitory effects.

bioRxiv · Sep 13, 2019Cell Biology

Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity

J.-A. Chan, D. Wetzel, L. Reiling, K. Miura, D. R. Drew, P. R. Gilson, D. A. Anderson, J. S. Richards, C. A. Long, M. Suckow, V. Jenzelewski, T. Tsuboi, M. J. Boyle, M. Piontek, J. G. Beeson

This study evaluates a novel virus-like particle platform for malaria vaccines, showing immunogenicity and transmission-blocking activity against Pfs230 and Pfs25 antigens.

bioRxiv · Aug 5, 2019Immunology

Knockdown of the translocon protein EXP2, reduces growth and protein export in malaria parasites.

P. R. Gilson, S. C. Charnaud, R. Kumarasingha, H. E. Bullen, B. S. Crabb

This study shows that knocking down EXP2 in malaria parasites reduces growth and protein export, suggesting EXP2 is essential for the PTEX translocon's function in exporting proteins into host cells.

bioRxiv · Sep 17, 2018Microbiology