B. S. Crabb

Aryl amino acetamides prevent the development of Plasmodium falciparum rings via inhibition of the lipid transfer protein PfSTART1

The paper identifies aryl amino acetamides that inhibit Plasmodium falciparum ring development by targeting PfSTART1, a lipid transfer protein, and shows these inhibitors block parasite transmission.

A pyridyl-furan series developed from Open Global Health Library blocks red blood cell invasion and protein trafficking in Plasmodium falciparum through potential inhibition of the parasites PI4KIIIb enzyme.

The paper identifies a pyridyl-furan compound series that inhibits Plasmodium falciparum growth and red blood cell invasion by targeting the PI4KIIIb enzyme.

The delayed bloodstream clearance of Plasmodium falciparum parasites after M5717 treatment is attributable to the inability to modify their red blood cell hosts.

This study shows M5717 delays Plasmodium falciparum parasite clearance by preventing host RBC modification, leading to reduced cytoadherence and splenic clearance.

The Dual Action of Human Antibodies Specific to Plasmodium falciparum PfRH5 and PfCyRPA: Blocking Invasion and Inactivating Extracellular Merozoites

This paper shows that antibodies against PfRH5 and PfCyRPA block parasite invasion and inactivate extracellular merozoites by triggering a developmental pathway normally seen after invasion.

PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum.

This study identifies PTEX150 as essential for trafficking haemoglobinases to the food vacuole in Plasmodium falciparum, revealing a new metabolic function for PTEX beyond the known permeability pathway.

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

The paper screens 400 anti-malarial compounds to identify inhibitors of protein export in Plasmodium falciparum, finding MMV396797 as a potent inhibitor that reduces parasite virulence.

High burden of Mycoplasma genitalium and other reproductive tract infections among pregnant women in Papua New Guinea

The paper reports a high prevalence of Mycoplasma genitalium and other treatable reproductive tract infections among pregnant women in Papua New Guinea, highlighting inadequate infection management and contraception use.

Knockdown of the translocon protein EXP2, reduces growth and protein export in malaria parasites.

This study shows that knocking down EXP2 in malaria parasites reduces growth and protein export, suggesting EXP2 is essential for the PTEX translocon's function in exporting proteins into host cells.