Author

T. Fontaine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 7 Organism:mouse· 3 Assay:proteomics· 3 Organism:E. coli· 2 Organism:fungi (other)· 2 Organism:Arabidopsis· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. BEAUSSART· 1 shared A. Goncalves· 1 shared A. Hounslow· 1 shared A. J. Crossen· 1 shared A. Mato-Lopez· 1 shared A. Morogovsky· 1 shared A. Roldan· 1 shared B. ROKBI· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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1 shared paperMicrobiology

A. BEAUSSART

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The unique Legionella longbeachae capsule favors intracellular replication and immune evasion

S. Schmidt, S. Mondino, L. Gomez-Valero, P. Escoll, D. P. Mascarenhas, A. Goncalves, C. Rusniok, M. Sachse, M. Moya-Nilges, T. Fontaine, D. S. Zamboni, C. Buchrieser

This study identifies a unique capsule in Legionella longbeachae that enhances intracellular replication and immune evasion, distinguishing it from other Legionella species.

bioRxiv · Nov 22, 2023 · PreprintMicrobiology

CD56-mediated activation of human natural killer cells is triggered by Aspergillus fumigatus galactosaminogalactan

L. Heilg, F. Natasha, N. Trinks, V. K. AIMANIANDA BOPAIAH, S. Sze Wah Wong, T. Fontaine, U. Terpitz, L. Strobel, F. Le Mauff, D. Sheppard, S. Schaeuble, O. Kurzai, K. Huenniger, E. Weiss, M. Vargas, , J. Loeffler

This study identifies galactosaminogalactan as the fungal ligand for CD56 on human NK cells, triggering antifungal responses and immune cell activation.

bioRxiv · Aug 18, 2023 · PreprintMicrobiology

Structural Remodeling of Fungal Cell Wall Promotes Resistance to Echinocandins

M. C. Dickwella Widanage, I. Gautam, D. Sarkar, F. Mentink-Vigier, J. V. Vermaas, T. Fontaine, J.-P. Latge, P. Wang, T. Wang

The paper investigates how fungal cell wall remodeling in response to echinocandins leads to drug resistance by altering carbohydrate polymer assembly and physical properties.

bioRxiv · Aug 9, 2023Biophysics

Bacterial capsular polysaccharides with antibiofilm activity share common biophysical and electrokinetic properties

J. BAYARD-BERNAL, J. THIEBAUD, M. BROSSAUD, A. BEAUSSART, C. CAILLET, Y. WALDVOGEL, L. TRAVIER, S. LETOFFE, T. FONTAINE, B. ROKBI, P. TALAGA, C. BELOIN, N. MISTRETTA, J. F. L. DUVAL, J.-M. GHIGO

This study identifies nine capsular polysaccharides with antibiofilm activity and shows they share common electrokinetic and biophysical properties distinguishing them from inactive polymers.

bioRxiv · May 27, 2022 · PreprintMicrobiology

Aspergillus fumigatus can display persistence to the fungicidal drug voriconazole

J. Scott, C. Valero, A. Mato-Lopez, I. J. Donaldson, A. Roldan, H. Chown, N. Van-Rhijn, R. Lobo-Vega, S. Gago, T. Furukawa, A. Morogovsky, R. Ben Ami, P. Bowyer, N. Osherov, T. Fontaine, , J. Amich

This study shows that some Aspergillus fumigatus isolates can persist in the presence of voriconazole, a fungicidal drug, and this persistence is associated with a distinct transcriptional profile and reduced treatment efficacy.

bioRxiv · May 16, 2022 · PreprintMicrobiology

The C-type Lectin Receptor Dectin-2 is a receptor for Aspergillus fumigatus galactomannan

J. L. Reedy, A. J. Crossen, P. E. Negoro, H. E. Brown, R. A. Ward, D. A. V. Blanco, K. D. Timmer, M. K. Mansour, M. Wüthrich, T. Fontaine, J.-P. Latgé, J. M. Vyas

This study identifies Dectin-2 as a receptor for Aspergillus fumigatus galactomannan, showing it mediates pro-inflammatory signaling and immune responses.

bioRxiv · Apr 12, 2022Immunology

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and resistance to innate immunity

R. E. Smith, B. Salamaga, P. Szkuta, N. H. Hajdamowicz, T. K. Prajsnar, G. Bulmer, T. Fontaine, J. Kołodziejczyk, J.-M. Herry, A. Hounslow, M. P. Williamson, P. Serror, S. Mesnage

This study identifies the role of EPA decoration in E. faecalis virulence, cell surface charge, and resistance to innate immunity.

bioRxiv · Dec 6, 2018Microbiology