Author

T. K. Prajsnar

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 5 Organism:zebrafish· 5 Research Focus:cell type annotation· 3 Organism:human· 2 Assay:imaging· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

S. A. Renshaw· 4 shared A. H. Meijer· 2 shared J. F. Gibson· 2 shared J. J. Serba· 2 shared J. Kolata· 2 shared K. D. Buchan· 2 shared M. van Gent· 2 shared N. V. Ogryzko· 2 shared

Activity by Year

2017-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersImmunology

S. A. Renshaw

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Author profile →

7 papers

Recent·Most cited

Dram1 confers resistance to Salmonella infection

S. Masud, R. Zhang, T. K. Prajsnar, A. H. Meijer

This study shows Dram1 enhances resistance to Salmonella infection by promoting LAP, a phagocytic autophagy mechanism, through ROS production and xenophagy.

bioRxiv · Mar 21, 2021Immunology

Neutrophils use selective autophagy receptor p62 to target Staphylococcus aureus for degradation in the zebrafish model

J. F. Gibson, T. K. Prajsnar, C. J. Hill, A. K. Tooke, J. J. Serba, R. D. Tonge, A. J. Grierson, P. W. Ingham, S. A. Renshaw, S. A. Johnston

This study shows p62 facilitates autophagy-mediated degradation of Staphylococcus aureus in zebrafish neutrophils.

bioRxiv · Feb 18, 2020Immunology

Human-specific staphylococcal virulence factors enhance pathogenicity in a humanised zebrafish C5a receptor model.

K. D. Buchan, M. van Gent, T. K. Prajsnar, N. V. Ogryzko, N. de Jong, J. Kolata, S. J. Foster, J. A. van Strijp, S. A. Renshaw

This study shows human-specific S. aureus toxins enhance pathogenicity in a humanised zebrafish model expressing the human C5a receptor.

bioRxiv · Feb 18, 2020Immunology

A transgenic zebrafish line for in vivo visualisation of neutrophil myeloperoxidase

K. D. Buchan, T. K. Prajsnar, N. V. Ogryzko, N. W. de Jong, M. van Gent, J. Kolata, S. J. Foster, J. A. G. A. Van Strijp, S. A. Renshaw

This paper introduces a transgenic zebrafish line expressing human MPO with a fluorescent tag to study neutrophil granule dynamics in vivo.

bioRxiv · Mar 20, 2019Immunology

The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils

T. K. Prajsnar, J. J. Serba, B. M. Dekker, J. F. Gibson, S. Masud, A. Fleming, S. A. Johnston, S. A. Renshaw, A. H. Meijer

This study shows that S. aureus uses autophagy to create an intracellular niche in neutrophils, while p62-mediated autophagy protects the host.

bioRxiv · Mar 18, 2019 · PreprintImmunology

Decoration of the enterococcal polysaccharide antigen EPA is essential for virulence, cell surface charge and resistance to innate immunity

R. E. Smith, B. Salamaga, P. Szkuta, N. H. Hajdamowicz, T. K. Prajsnar, G. Bulmer, T. Fontaine, J. Kołodziejczyk, J.-M. Herry, A. Hounslow, M. P. Williamson, P. Serror, S. Mesnage

This study identifies the role of EPA decoration in E. faecalis virulence, cell surface charge, and resistance to innate immunity.

bioRxiv · Dec 6, 2018Microbiology

Fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum

X. Zhang, A. M. Guzman Prieto, V. de Maat, T. K. Prajsnar, J. R. Bayjanov, M. de Been, M. R. C. Rogers, M. J. M. Bonten, S. Mesnage, R. J. L. Willems, W. van Schaik

This study identifies genes essential for vancomycin-resistant Enterococcus faecium growth in human serum and their role in virulence.

bioRxiv · Jan 21, 2017Microbiology