Author

M. R. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

P. R. Griffin· 3 shared T. S. Strutzenberg· 2 shared Y. He· 2 shared C. Doebelin· 1 shared C. Doebellin· 1 shared H. Park· 1 shared R. D. Garcia-Ordonez· 1 shared R. Garcia-Ordonez· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBiophysics

P. R. Griffin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RORβ modulates a gene program that is protective against articular cartilage damage

P. R. Griffin, M. R. Chang

This study shows that RORβ modulates a gene program that supports chondrogenesis and protects against OA by regulating FGFR signaling pathways.

bioRxiv · May 5, 2022Cell Biology

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.

T. S. Strutzenberg, S. J. Novick, R. D. Garcia-Ordonez, C. Doebelin, Y. He, M. R. Chang, T. M. Kamenecka, P. R. Griffin

This study investigates conformational changes in RORγ during DNA recognition and coregulator engagement using structural proteomics and small angle X-ray scattering.

bioRxiv · May 25, 2021Biophysics

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

T. S. Strutzenberg, R. Garcia-Ordonez, S. Novick, H. Park, M. R. Chang, C. Doebellin, Y. He, R. Patouret, T. Kamenecka, P. R. Griffin

This study uses HDX-MS to identify structural determinants of RORγ hyperactivation by synthetic agonists, showing correlations between receptor dynamics and activity.

bioRxiv · Mar 26, 2019Biophysics