Author

T. S. Strutzenberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Organism:human· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

P. R. Griffin· 3 shared M. R. Chang· 2 shared Y. He· 2 shared A. A. Deniz· 1 shared A. Biswas· 1 shared A. N. Engelman· 1 shared B. MacTavish· 1 shared B. Zhou· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

P. R. Griffin

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Author profile →

4 papers

Recent·Most cited

Oligomeric HIV-1 Integrase Structures Reveal Functional Plasticity for Intasome Assembly and RNA Binding

T. Jing, Z. Shan, T. Dinh, A. Biswas, S. Jang, J. Greenwood, M. Li, Z. Zhang, G. Gray, H. J. Shin, B. Zhou, D. Passos, T. S. Strutzenberg, S. Aiyer, L. Andrade, , D. Lyumkis

This study determines cryo-EM structures of HIV-1 integrase tetramers and intasome hexadecamers, revealing structural plasticity and functional roles in viral integration and RNA binding.

bioRxiv · Jan 26, 2024 · PreprintBiochemistry

Structural basis of interdomain communication in PPARγ

S. A. Mosure, P. Munoz-Tello, K.-T. Kuo, B. MacTavish, X. Yu, D. Scholl, C. C. Williams, T. S. Strutzenberg, J. Li, J. Bass, R. Brust, E. Kalkhoven, A. A. Deniz, P. R. Griffin, D. Kojetin

This study identifies a conserved Trp-Pro motif in PPARγ AF-1 that undergoes cis/trans isomerization, enabling interdomain communication with the LBD and affecting transcriptional activity.

bioRxiv · Jul 13, 2022 · PreprintBiophysics

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement.

T. S. Strutzenberg, S. J. Novick, R. D. Garcia-Ordonez, C. Doebelin, Y. He, M. R. Chang, T. M. Kamenecka, P. R. Griffin

This study investigates conformational changes in RORγ during DNA recognition and coregulator engagement using structural proteomics and small angle X-ray scattering.

bioRxiv · May 25, 2021Biophysics

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

T. S. Strutzenberg, R. Garcia-Ordonez, S. Novick, H. Park, M. R. Chang, C. Doebellin, Y. He, R. Patouret, T. Kamenecka, P. R. Griffin

This study uses HDX-MS to identify structural determinants of RORγ hyperactivation by synthetic agonists, showing correlations between receptor dynamics and activity.

bioRxiv · Mar 26, 2019Biophysics