Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor
O. Danziger, R. S. Patel, E. J. DeGrace, M. R. Rosen, B. R. Rosenberg
This study uses an inducible CRISPR activation screen to identify ISGs that restrict SARS-CoV-2, confirming OAS1 as a restriction factor with catalytic activity required for antiviral effects.
bioRxiv · Sep 22, 2021Microbiology