Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
A. Lercher, J.-G. Cheong, C. Jiang, H.-H. Hoffmann, A. W. Ashbrook, Y. S. Yin, C. Quirk, E. J. DeGrace, L. Chiriboga, B. R. Rosenberg, S. Z. Josefowicz, C. M. Rice
This study shows that SARS-CoV-2 infection primes alveolar macrophages for enhanced antiviral responses against influenza A virus through epigenetic changes in IFN-I pathways.
bioRxiv · Nov 24, 2023 · PreprintImmunology
R. A. Prescott, A. P. Pankow, M. de Vries, K. Crosse, R. S. Patel, M. Alu, C. Loomis, V. Torres, S. B. Koralov, E. N. Ivanova, M. Dittmann, B. R. Rosenberg
This study compares gene expression and cellular heterogeneity in HAE cultures derived from BCi-NS1.1 cell lines and primary cells using scRNA-Seq, finding similar morphology and transcriptional patterns but some interferon gene differences.
bioRxiv · Feb 27, 2023 · PreprintCell Biology
T. Kehrer, A. Cupic, C. Ye, S. Yildiz, M. Bouhhadou, N. A. Crossland, E. Barrall, P. Cohen, A. Tseng, T. Cagatay, R. Rathnasinghe, D. Flores, S. Jangra, F. Alam, N. Mena, , L. Miorin
This study shows SARS-CoV-2 ORF6 disrupts nucleo-cytoplasmic trafficking, inhibits IFN signaling, and modulates viral protein expression, with variant polymorphisms affecting its function.
bioRxiv · Oct 18, 2022Microbiology
J. A. Acklin, A. R. Patel, A. P. Kurland, S. Horiuchi, A. S. Moss, E. J. Degrace, S. Ikegame, J. Carmichael, S. Kowdle, P. Thibault, N. Imai, H. Ueno, B. Tweel, J. R. Johnson, B. R. Rosenberg, , J. K. Lim
The paper infects human lymphoid explants with measles virus and uses scRNA-Seq and flow cytometry to identify B cell preference and T cell resistance, along with ISG protein induction.
bioRxiv · Sep 12, 2022Immunology
P. Cohen, E. J. DeGrace, O. Danziger, R. Patel, E. A. Barrall, T. Bobrowski, T. Kehrer, A. Cupic, L. Miorin, A. Garcia-Sastre, B. R. Rosenberg
This study evaluates scRNA-Seq methods for detecting SARS-CoV-2 subgenomic mRNAs, finding that 10X 5' with extended R1 sequencing best captures these viral RNAs at single-cell resolution.
bioRxiv · Nov 22, 2021Microbiology
O. Danziger, R. S. Patel, E. J. DeGrace, M. R. Rosen, B. R. Rosenberg
This study uses an inducible CRISPR activation screen to identify ISGs that restrict SARS-CoV-2, confirming OAS1 as a restriction factor with catalytic activity required for antiviral effects.
bioRxiv · Sep 22, 2021Microbiology
C. A. Higgins, B. E. Nilsson-Payant, A. Kurland, C. Ye, T. M. Yaron, J. L. Johnson, B. Bonaventure, P. Adhikary, I. Golynker, B. R. Rosenberg, O. Danziger, M. Panis, L. C. Cantley, L. Martinez-Sobrido, B. R. tenOever, J. R. Johnson
This study identifies p38β as a critical host factor for SARS-CoV-2 replication and shows that inhibiting it reduces viral replication and cytokine production.
bioRxiv · Aug 20, 2021 · PreprintMicrobiology
C. N. Gruber, J. Calis, S. Buta, G. Evrony, J. C. Martin, S. Uhl, R. Caron, L. Jarchin, D. Dunkin, R. Phelps, B. D. Webb, J. Saland, M. Merad, J. Orange, E. M. Mace, , D. Bogunovic
This study identifies a JAK1 mutation causing autoinflammation and shows its unique transcriptional and functional effects through single-cell analysis and clinical treatment.
Immunity · Sep 1, 2020Peer-reviewedImmunology
R. S. Patel, J. E. Tomlinson, T. J. Divers, G. R. Van de Walle, B. R. Rosenberg
This study uses scRNA-Seq to characterize immune cell diversity in equine PBMCs, identifying novel T-bet+ B cells and revealing similarities and differences with human immune cells.
bioRxiv · May 5, 2020Immunology
L. L. Seifert, C. Si, S. Ballentine, D. Saha, M. de Vries, G. Wang, M. Sadic, A. Briley, U. Schaefer, H. Moulton, A. Garcia-Sastre, S. Tripathi, B. R. Rosenberg, M. Dittmann
This paper identifies ELF1 as a non-canonical regulator of antiviral ISG expression, showing it amplifies and prolongs the type I interferon response by inducing a distinct set of antiviral genes.
bioRxiv · Feb 14, 2019Immunology