Author

E. J. DeGrace

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

B. R. Rosenberg· 4 shared O. Danziger· 2 shared A. Cupic· 1 shared A. Garcia-Sastre· 1 shared A. Lercher· 1 shared A. P. Kurland· 1 shared A. R. Patel· 1 shared A. S. Moss· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersImmunology

B. R. Rosenberg

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Antiviral innate immune memory in alveolar macrophages following SARS-CoV-2 infection.

A. Lercher, J.-G. Cheong, C. Jiang, H.-H. Hoffmann, A. W. Ashbrook, Y. S. Yin, C. Quirk, E. J. DeGrace, L. Chiriboga, B. R. Rosenberg, S. Z. Josefowicz, C. M. Rice

This study shows that SARS-CoV-2 infection primes alveolar macrophages for enhanced antiviral responses against influenza A virus through epigenetic changes in IFN-I pathways.

bioRxiv · Nov 24, 2023 · PreprintImmunology

Immunological landscape of human lymphoid explants during measles virus infection

J. A. Acklin, A. R. Patel, A. P. Kurland, S. Horiuchi, A. S. Moss, E. J. Degrace, S. Ikegame, J. Carmichael, S. Kowdle, P. Thibault, N. Imai, H. Ueno, B. Tweel, J. R. Johnson, B. R. Rosenberg, , J. K. Lim

The paper infects human lymphoid explants with measles virus and uses scRNA-Seq and flow cytometry to identify B cell preference and T cell resistance, along with ISG protein induction.

bioRxiv · Sep 12, 2022Immunology

Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single cell RNA sequencing

P. Cohen, E. J. DeGrace, O. Danziger, R. Patel, E. A. Barrall, T. Bobrowski, T. Kehrer, A. Cupic, L. Miorin, A. Garcia-Sastre, B. R. Rosenberg

This study evaluates scRNA-Seq methods for detecting SARS-CoV-2 subgenomic mRNAs, finding that 10X 5' with extended R1 sequencing best captures these viral RNAs at single-cell resolution.

bioRxiv · Nov 22, 2021Microbiology

Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor

O. Danziger, R. S. Patel, E. J. DeGrace, M. R. Rosen, B. R. Rosenberg

This study uses an inducible CRISPR activation screen to identify ISGs that restrict SARS-CoV-2, confirming OAS1 as a restriction factor with catalytic activity required for antiviral effects.

bioRxiv · Sep 22, 2021Microbiology