R. S. Patel

A comparative study of in vitro air-liquid interface culture models of the human airway epithelium evaluating cellular heterogeneity and gene expression at single cell resolution

This study compares gene expression and cellular heterogeneity in HAE cultures derived from BCi-NS1.1 cell lines and primary cells using scRNA-Seq, finding similar morphology and transcriptional patterns but some interferon gene differences.

Machine-Learning Based Optimisation of a Biomimiced Herringbone Microstructure for Superior Aerodynamic Performance.

The paper optimizes a herringbone microstructure inspired by bird feathers using CFD and machine learning to achieve drag reduction.

Inducible CRISPR activation screen for interferon-stimulated genes identifies OAS1 as a SARS-CoV-2 restriction factor

This study uses an inducible CRISPR activation screen to identify ISGs that restrict SARS-CoV-2, confirming OAS1 as a restriction factor with catalytic activity required for antiviral effects.

The Dual-Antigen Ad5 COVID-19 Vaccine Delivered as an Intranasal Plus Subcutaneous Prime Elicits Th1 Dominant T-Cell and Humoral Responses in CD-1 Mice

This study evaluates a dual-antigen Ad5 vaccine delivered via subcutaneous and intranasal routes in mice, showing that combined prime-only delivery elicits strong humoral and T-cell responses against SARS-CoV-2.

A recombinant ACE2 Triple Decoy that traps and neutralizes SARS-CoV-2 shows enhanced affinity for highly transmissible SARS-CoV-2 variants

The paper develops an ACE2 Triple Decoy that maintains high affinity for SARS-CoV-2 variants and shows enhanced affinity for specific mutations.

Multi-omic Characterization of Human Tubular Epithelial Cell Response to Serum

The paper characterizes the transcriptional and epigenomic response of human tubular epithelial cells to serum exposure, identifying key regulatory programs and gene signatures.

A Next Generation Bivalent Human Ad5 COVID-19 Vaccine Delivering Both Spike and Nucleocapsid Antigens Elicits Th1 Dominant CD4+, CD8+ T-cell and Neutralizing Antibody Responses

This paper describes a bivalent hAd5 vaccine combining S-Fusion and N-ETSD antigens that elicits strong Th1-biased T-cell and neutralizing antibody responses in pre-clinical models.

Single cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse immune cell subtypes including T-bet+ B cells

This study uses scRNA-Seq to characterize immune cell diversity in equine PBMCs, identifying novel T-bet+ B cells and revealing similarities and differences with human immune cells.

Drosophila Sex Peptide Controls the Assembly of Lipid Microcarriers in Seminal Fluid

This paper shows that Sex Peptide in Drosophila is essential for assembling lipid microcarriers in seminal fluid, which are transferred to females and disassembled, with SP also required for normal female disassembly.