A lipopeptidomimetic of transcriptional activation domains selectively disrupts Med25 PPIs
O. N. Pattelli, E. Martinez Valdivia, M. S. Beyersdorf, C. S. Regan, M. Rivas, S. D. Merajver, T. Cierpicki, A. K. Mapp
The paper develops a lipopeptidomimetic that selectively disrupts Med25 protein-protein interactions, showing improved affinity and selectivity for Med25 over other coactivators.
bioRxiv · Mar 24, 2023 · PreprintBiochemistry