Author

A. K. Mapp

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. D. Merajver· 3 shared C. L. Brooks· 2 shared J. A. Yates· 2 shared J. M. Garlick· 2 shared Y. Liu· 2 shared A. L. Peiffer· 1 shared A. Peiffer· 1 shared C. S. Regan· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiochemistry

S. D. Merajver

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Inhibition of CREB binding and function with a dual-targeting ligand

Y. Liu, S. T. Joy, M. J. Henley, J. A. Yates, S. D. Merajver, A. K. Mapp

This study develops a dual-targeting ligand, CREBLL-tide, that inhibits the KIX-CREB PPI with high potency and selectivity, showing anti-proliferation activity in breast cancer cells.

bioRxiv · Sep 3, 2023Biochemistry

A lipopeptidomimetic of transcriptional activation domains selectively disrupts Med25 PPIs

O. N. Pattelli, E. Martinez Valdivia, M. S. Beyersdorf, C. S. Regan, M. Rivas, S. D. Merajver, T. Cierpicki, A. K. Mapp

The paper develops a lipopeptidomimetic that selectively disrupts Med25 protein-protein interactions, showing improved affinity and selectivity for Med25 over other coactivators.

bioRxiv · Mar 24, 2023 · PreprintBiochemistry

Norstictic acid is a selective allosteric transcriptional regulator

J. M. Garlick, S. M. Sturlis, P. A. Bruno, J. A. Yates, A. Peiffer, Y. Liu, L. Goo, L. Bao, S. De Salle, G. Tamayo-Castillo, C. L. Brooks, S. D. Merajver, A. K. Mapp

This study identifies norstictic acid as a selective allosteric inhibitor of Med25-mediated transcriptional interactions, showing its effect in vitro and in a breast cancer model.

bioRxiv · Mar 26, 2021Biochemistry

TMPRSS2 inhibitor discovery facilitated through an in silico and biochemical screening platform

A. L. Peiffer, J. M. Garlick, Y. Wu, M. B. Soellner, C. L. Brooks, A. K. Mapp

The paper identifies TMPRSS2 inhibitors using a combination of virtual screening and biochemical assays, revealing both covalent and non-covalent inhibitors.

bioRxiv · Mar 22, 2021Biochemistry