Author

M. Royzen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:long-read sequencing· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

j. Sheng· 2 shared A. Hoy· 1 shared A. Mahmoodi· 1 shared I. Khan· 1 shared J. M. Mejia Oneto· 1 shared K. Wu· 1 shared M. He· 1 shared M. Zakharian· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

j. Sheng

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Author profile →

3 papers

Recent·Most cited

Bio-orthogonal chemistry-based conjugation strategy facilitates investigation of impacts of s2U, s4U, m1A and m6A guide RNA modifications on CRISPR activity.

A. Hoy, Y. Y. Zheng, j. Sheng, M. Royzen

The paper develops a bio-orthogonal conjugation strategy to efficiently assemble modified sgRNAs and investigates their impact on CRISPR activity.

bioRxiv · Jun 9, 2022 · PreprintBiochemistry

SQ3370 Activates Cytotoxic Drug via Click Chemistry at Tumor and Elicits Sustained Responses in Injected & Non-injected Lesions

S. Srinivasan, N. A. Yee, K. Wu, M. Zakharian, A. Mahmoodi, M. Royzen, J. M. Mejia Oneto

SQ3370 activates a cytotoxic drug at tumors via click chemistry, improving survival and inducing systemic anti-tumor responses in mice with injected and non-injected lesions.

bioRxiv · Oct 13, 2020Bioengineering

Bio-Orthogonal Chemistry Enables Solid Phase Synthesis of Long RNA Oligonucleotides

M. He, P. Haruehanroengra, I. Khan, J. Sheng, M. Royzen

This paper develops a bio-orthogonal chemistry method for synthesizing long RNA oligonucleotides, achieving 76-nt tRNA and 101-nt sgRNA with high purity and functional fidelity.

bioRxiv · Oct 9, 2020Biochemistry