I. Khan

IMD-mediated innate immune priming increases Drosophila survival and reduces pathogen transmission

This study shows that immune priming in Drosophila enhances survival and reduces pathogen transmission by requiring the IMD pathway and Diptericin-B.

PATHOGEN GROWTH AND VIRULENCE DYNAMICS DRIVE THE HOST EVOLUTION AGAINST COINFECTIONS

This study shows that host evolution against coinfections is influenced by the growth and virulence dynamics of individual pathogens, with fast-acting pathogens hindering adaptive success.

Characterization of the novel SmsHSP24.1 Promoter: Unveiling its abiotic stress-inducible expression in transgenic Eggplant (Solanum melongena L.)

This study characterizes the SmsHSP24.1 promoter in eggplant, showing its inducible expression under abiotic stresses and its potential as a tool for crop improvement.

Dissociable encoding of motivated behavior by parallel thalamo-striatal projections

This study identifies two distinct PVT neuronal populations that encode different aspects of motivated behavior in mice during a reward foraging task.

Wound healing and anti-inflammatory potential of Ajuga bracteosa-conjugated silver nanoparticles in Balb/c mice

This study evaluates the wound healing and anti-inflammatory effects of Ajuga bracteosa-conjugated silver nanoparticles in Balb/c mice, finding they promote wound contraction and reduce inflammation.

Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer.

This study compares three transcytotic pathways for drug delivery to brain metastases of breast cancer and finds that albumin shows optimal distribution and uses a novel clathrin-independent endocytosis mechanism.

Disruption of flour beetle microbiota limits experimentally evolved immune priming response, but not pathogen resistance

This study shows that disrupting the microbiota of flour beetles eliminates immune priming but not pathogen resistance, indicating divergent microbiome reliance in evolved immune strategies.

Ageing leads to nonspecific antimicrobial peptide responses in Drosophila melanogaster

This study shows that ageing in Drosophila melanogaster reduces the specificity of antimicrobial peptide (AMP) responses, requiring multiple AMPs for survival, while young flies can resist infections with single AMPs.

Interaction of Fungal lipase with potential phytotherapeutics

This study investigates the interaction of thymol, carvacrol, and linalool with fungal lipase and HSA using spectroscopy and docking, finding thymol most effective in disrupting lipase structure.

THE COSTS AND BENEFITS OF BASAL INFECTION RESISTANCE VS DIVERSE IMMUNE PRIMING RESPONSES IN AN INSECT

This study compares the fitness costs and benefits of immune priming versus basal resistance in Tribolium beetles, finding resistance provides greater reproductive and survival advantages with no hidden costs.

Sexual conflict drives micro- and macroevolution of sexual dimorphism in immunity

This study shows that sexual conflict influences sexual dimorphism in immunity through molecular and phenotypic changes in seed beetles.

Bio-Orthogonal Chemistry Enables Solid Phase Synthesis of Long RNA Oligonucleotides

This paper develops a bio-orthogonal chemistry method for synthesizing long RNA oligonucleotides, achieving 76-nt tRNA and 101-nt sgRNA with high purity and functional fidelity.

CARCASS SCAVENGING RELAXES CHEMICAL-DRIVEN FEMALE INTERFERENCE COMPETITION

The paper shows that scavenging nutrient-rich carcasses reduces chemical-driven female interference competition in flour beetles by increasing fecundity and reducing quinone content.

The MEK1/2 pathway as a therapeutic target in high-grade serous ovarian carcinoma

This study investigates MEK1/2 pathway activity in high-grade serous ovarian carcinoma and shows that its inhibition reduces tumor growth but promotes stem-like properties, suggesting potential resistance mechanisms.

Pathogen susceptibility and fitness costs explain variation in immune priming across natural populations of flour beetles

This study investigates how pathogen susceptibility and reproductive costs influence immune priming variation in flour beetles across populations.

Experimental Evolution Of Insect Immune Memory Vs. Pathogen Resistance

This study shows that repeated exposure to pathogens in flour beetles leads to either generalized resistance or specific immune priming, with distinct evolutionary outcomes.

FEMALE CHEMICAL WARFARE DRIVES FITNESS EFFECTS OF GROUP SEX RATIO

The paper investigates how female chemical warfare via quinones affects fitness in flour beetles with skewed sex ratios, showing non-sexual competition reduces female fecundity in female-biased groups.