Bio-Orthogonal Chemistry Enables Solid Phase Synthesis of Long RNA Oligonucleotides
M. He, P. Haruehanroengra, I. Khan, J. Sheng, M. Royzen
This paper develops a bio-orthogonal chemistry method for synthesizing long RNA oligonucleotides, achieving 76-nt tRNA and 101-nt sgRNA with high purity and functional fidelity.
bioRxiv · Oct 9, 2020Biochemistry