Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity.
F. Inesta-Vaquera, P. Navasumrit, C. J. Henderson, T. G. Frangova, T. Honda, A. T. Dinkova-Kostova, M. Ruchirawat, C. R. Wolf
This study uses Hmox1 reporter mice to demonstrate iAs-induced oxidative stress and validate N-acetyl cysteine as a potential therapy for arsenic toxicity.
bioRxiv · Jun 19, 2020Pharmacology & Toxicology